Insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Insulin-like growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP1, EFEMP2, and TAP1_T545, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin-like growth factor receptor signaling pathway activity versus EFEMP1 in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EFEMP1 →	+0.390	+0.031	.001	<.001	3	6
BRCA	EFEMP2 →	+0.607	+0.043	<.001	<.001	3	6
BRCA	TAP1_T545 →	-1.688	-0.052	<.001	<.001	3	5
BRCA	TAPBP →	-0.551	-0.034	<.001	<.001	3	5
HNSC	WARS1 →	-0.933	-0.059	<.001	<.001	3	5
CCRCC	FCER1G →	-0.540	-0.032	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048009 vs EFEMP1 — BRCA

Explore this scatter interactively →