Insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC5, KLHL4, and SH3D19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin-like growth factor receptor signaling pathway activity versus PABPC5 in LUAD (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PABPC5 →	+0.228	+0.116	.006	.003	3	5
BRCA	KLHL4 →	+0.260	+0.177	.003	<.001	3	4
BRCA	SH3D19 →	+0.508	+0.140	.003	<.001	3	4
BRCA	PLSCR4 →	+0.969	+0.197	.001	.001	3	4
LSCC	PPFIA2 →	+0.325	+0.112	<.001	<.001	3	4
BRCA	KERA →	+0.521	+0.123	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048009 vs PABPC5 — LUAD

Explore this scatter interactively →