Insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HCC1, CNOT7, and DAZAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin-like growth factor receptor signaling pathway activity versus R3HCC1 in OVARY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	R3HCC1 →	+1.424	+1.458	<.001	<.001	3	4
OVARY	CNOT7 →	+0.783	+0.933	<.001	<.001	3	4
OVARY	DAZAP1 →	+0.892	+1.308	<.001	.001	3	4
SOFT_TISSUE	PPM1G →	+0.922	+1.579	.004	<.001	2	5
PANCREAS	POP1 →	+1.207	+1.176	.001	.008	3	4
PANCREAS	POLD1 →	+1.001	+1.043	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048009 vs R3HCC1 — OVARY

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