Vesicle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Vesicle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC2, KIAA1109, and ZBTB39, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle transport along microtubule activity versus HERC2 in SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	HERC2 →	+1.280	+0.102	<.001	<.001	3	33
DLBC	KIAA1109 →	+1.152	+0.042	<.001	<.001	3	33
TGCT	ZBTB39 →	+1.000	+0.041	<.001	<.001	3	33
DLBC	NR2C2 →	+1.372	+0.042	<.001	<.001	3	33
DLBC	ZNF354B →	+1.010	+0.052	<.001	.003	3	33
UCS	GPATCH8 →	+1.125	+0.061	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0047496 vs HERC2 — SCLC

Explore this scatter interactively →