Vesicle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Vesicle transport along microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK3, MAP2, and ERO1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle transport along microtubule activity versus HK3 in PDAC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HK3 →	-0.540	-0.034	<.001	<.001	3	6
LSCC	MAP2 →	+0.605	+0.045	<.001	<.001	3	6
PDAC	ERO1A →	-0.441	-0.031	.003	.001	3	6
HNSC	MAP2_S1480 →	+1.425	+0.073	<.001	.002	3	6
GBM	MICALL1 →	-0.330	-0.043	<.001	.002	3	6
LSCC	MLKL →	-0.341	-0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0047496 vs HK3 — PDAC

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