Vesicle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Vesicle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP3, CCDC92, and TSNAXIP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP3 grouped by Vesicle transport along microtubule-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SENP3 →	-0.456	-0.716	<.001	.009	3	3
LARGE_INTESTINE	CCDC92 →	+0.769	+0.553	.005	.007	3	3
CNS	TSNAXIP1 →	-0.718	-1.066	.002	.002	3	3
CNS	SLC25A35 →	-0.787	-1.160	<.001	<.001	3	3
LUNG_NSCLC_LUAD	RPRD2 →	+0.650	+0.944	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ASNS →	+1.027	+0.782	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP3 by Vesicle transport along microtubule activity — OVARY

Explore this box plot interactively →