Regulation of response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Regulation of response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL_S246, WDFY4, and EVL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to osmotic stress activity versus EVL_S246 in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EVL_S246 →	-0.669	-0.071	<.001	<.001	3	5
HNSC	WDFY4 →	-0.461	-0.076	<.001	<.001	3	5
HNSC	EVL →	-0.504	-0.072	<.001	<.001	3	5
LSCC	EVL_S331 →	-0.586	-0.069	.001	<.001	3	5
HNSC	GRAP2 →	-0.366	-0.062	<.001	<.001	3	5
HNSC	PLEK →	-0.309	-0.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0047484 vs EVL_S246 — HNSC

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