Regulation of response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Regulation of response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, HSPE1, and KL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to osmotic stress activity versus ARHGEF2 in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF2 →	+0.506	+0.184	.002	.005	3	4
BRCA	HSPE1 →	+0.617	+0.246	<.001	<.001	3	3
BRCA	KL →	-0.613	-0.222	<.001	.001	3	3
BRCA	BAIAP2L1 →	+0.658	+0.237	.002	.005	3	3
HNSC	EFS →	-0.660	-0.110	.003	.007	3	3
HNSC	AKR1B10 →	-1.394	-0.107	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0047484 vs ARHGEF2 — UCEC

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