Regulation of lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, FTH1, and PLRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYBL2 grouped by Regulation of lipid biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYBL2 →	-0.511	-0.098	.003	.002	3	4
CNS	FTH1 →	+0.138	+0.033	.007	.001	3	4
CNS	PLRG1 →	-0.279	-0.033	.001	.003	2	5
CNS	SLC52A2 →	-0.210	-0.050	.001	.001	3	4
SOFT_TISSUE	CRYGB →	-0.327	-0.070	.003	.001	3	4
OVARY	RRM2B →	-0.185	-0.032	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYBL2 by Regulation of lipid biosynthetic process activity — BONE

Explore this box plot interactively →