Positive regulation of lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RLIM, EIF4EBP2, and FOXO4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid biosynthetic process activity versus RLIM in BONE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RLIM →	-0.686	-0.284	.004	.006	3	4
OVARY	EIF4EBP2 →	-0.722	-0.262	.002	.003	3	4
OVARY	FOXO4 →	-0.830	-0.247	.007	.003	3	4
LUNG_NSCLC_LUAD	CYSRT1 →	-2.399	-0.366	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TPST1 →	+1.131	+0.267	<.001	<.001	2	5
LUNG_NSCLC_LUAD	STX2 →	+0.932	+0.295	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046889 vs RLIM — BONE

Explore this scatter interactively →