Negative regulation of hormone secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHBP1_S1058, U2SURP, and STC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hormone secretion activity versus EHBP1_S1058 in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EHBP1_S1058 →	+0.603	+0.036	<.001	.004	3	7
BRCA	U2SURP →	-0.245	-0.029	<.001	<.001	3	7
GBM	STC1 →	+0.923	+0.029	<.001	<.001	3	7
OV	SNRNP70 →	-0.560	-0.023	.002	.006	3	6
OV	SNRPD2 →	-0.212	-0.024	.002	.001	3	6
GBM	LMNB1 →	-0.326	-0.038	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046888 vs EHBP1_S1058 — LSCC

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