Positive regulation of hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, TK1, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone secretion activity versus ATAD2_S342 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATAD2_S342 →	-0.736	-0.014	<.001	<.001	3	7
UCEC	TK1 →	-0.534	-0.028	<.001	<.001	3	7
GBM	CNRIP1 →	+0.596	+0.041	<.001	<.001	3	7
BRCA	GNPDA2 →	+0.516	+0.026	<.001	<.001	3	7
UCEC	MCM4_T110 →	-1.333	-0.042	<.001	<.001	3	7
OV	GRPEL1 →	-0.377	-0.018	.009	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046887 vs ATAD2_S342 — BRCA

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