Positive regulation of hormone secretion

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of hormone secretion pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 141 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Positive regulation of hormone secretion pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and KIRP, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRP, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.889	0.795	<.001	39	view →
KIRP	OS	Tertile	All	0.983	0.900	.013	19	view →
PAAD	DFS	Tertile	All	0.396	0.202	.004	19	view →
CHOL	OS	Median	All	0.496	0.897	.007	18	view →
READ	DFS	Tertile	IV	0.184	0.649	.001	12	view →
ESCA	OS	Median	III,IV	0.680	0.331	.015	10	view →
SCLC	OS	Median	All	0.400	1.000	<.001	10	view →
THCA	OS	Median	III,IV	0.723	0.966	.003	9	view →
COAD	DFS	Median	All	0.706	0.822	.008	7	view →
SKCM	DFS	Tertile	IV	0.163	0.628	.036	7	view →
LIHC	OS	Tertile	II,III,IV	0.559	0.745	.036	7	view →
KIRC	DFS	Quartile	All	0.473	0.666	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0046887–LGG (DFS)

Open the LGG breakdown →