Positive regulation of hormone secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, GBP3, and ASTN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone secretion activity versus PIF1 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PIF1 →	+0.746	+0.152	<.001	.001	3	5
CNS	GBP3 →	+1.303	+0.161	.006	.001	3	5
LIVER	ASTN2 →	-0.852	-0.304	.008	.003	3	4
OVARY	CLDN1 →	+4.273	+0.224	<.001	.004	3	4
KIDNEY	NUSAP1 →	+1.214	+0.208	.003	.004	3	4
BLOOD_Lymphoma	GPSM1 →	-1.554	-0.157	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046887 vs PIF1 — BLOOD_Lymphoma

Explore this scatter interactively →