Regulation of hormone secretion

Across TCGA patient cohorts, RNA activity of the Regulation of hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SON, CD99, and DDX42, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone secretion activity versus SON in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SON →	-0.248	-0.031	<.001	.001	3	6
UCEC	CD99 →	+0.462	+0.026	.001	<.001	3	6
GBM	DDX42 →	-0.257	-0.039	.002	<.001	3	6
GBM	DNTTIP2 →	-0.295	-0.035	.001	<.001	3	6
GBM	EFTUD2 →	-0.230	-0.032	.003	.001	3	6
BRCA	ATAD2_S342 →	-0.832	-0.019	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046883 vs SON — GBM

Explore this scatter interactively →