Regulation of hormone secretion

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of hormone secretion pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 253 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Regulation of hormone secretion pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BLCA, show the opposite pattern, with higher activity associated with better survival.

THCA, HNSC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	III,IV	0.680	0.968	.002	33	view →
HNSC	DFS	Median	IV	0.456	0.231	<.001	33	view →
STAD	DFS	Median	All	0.473	0.597	.003	29	view →
BLCA	OS	Tertile	All	0.797	0.691	.015	26	view →
ESCA	DFS	Median	III,IV	0.452	0.218	.005	26	view →
SKCM	OS	Tertile	III,IV	0.549	0.316	.003	26	view →
LIHC	DFS	Median	All	0.264	0.479	.003	24	view →
UVM	DFS	Median	III,IV	0.874	0.511	.006	19	view →
SCLC	OS	Median	IV	0.959	0.274	.010	15	view →
COAD	DFS	Median	All	0.732	0.809	.003	13	view →
READ	OS	Median	II,III,IV	0.973	0.866	.023	13	view →
THYM	OS	Median	II,III,IV	0.716	0.959	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0046883–THCA (OS)

Open the THCA breakdown →