Regulation of hormone secretion

Across TCGA cell cohorts, RNA activity of the Regulation of hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF13, POLR1G, and MRPL15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone secretion activity versus DCAF13 in LARGE_INTESTINE (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCAF13 →	-0.647	-0.157	.002	<.001	3	6
SKIN	POLR1G →	-0.719	-0.179	<.001	.002	3	5
SKIN	MRPL15 →	-0.634	-0.145	.006	.002	3	5
UPPER_AERODIGESTIVE_TRACT	ADSL →	-1.186	-0.136	.003	.005	3	4
URINARY_TRACT	PLLP →	+2.846	+0.259	<.001	.001	3	4
URINARY_TRACT	P2RX4 →	+1.868	+0.267	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046883 vs DCAF13 — LARGE_INTESTINE

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