Regulation of saliva secretion

Across TCGA patient cohorts, RNA activity of the Regulation of saliva secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S864, TKT_S295, and PPP3CA_S462, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of saliva secretion activity versus SYNPO_S864 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNPO_S864 →	+0.708	+0.641	<.001	<.001	3	3
GBM	TKT_S295 →	-0.414	-0.564	<.001	<.001	3	3
BRCA	PPP3CA_S462 →	+1.387	+0.652	<.001	.002	3	3
GBM	ROGDI →	+0.394	+0.505	<.001	<.001	3	2
BRCA	RREB1_S1653 →	+0.409	+0.516	<.001	.001	3	2
BRCA	ZBTB7B_S172 →	+0.677	+0.674	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046877 vs SYNPO_S864 — GBM

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