Quinolinate metabolic process

Across TCGA patient cohorts, RNA activity of the Quinolinate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACC1, DOCK8, and ARHGAP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinolinate metabolic process activity versus TACC1 in BRCA (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TACC1 →	+0.896	+0.121	<.001	<.001	3	7
LSCC	DOCK8 →	+0.809	+0.125	<.001	<.001	3	6
UCEC	ARHGAP9 →	+0.715	+0.140	<.001	.001	3	6
LSCC	MYO1F →	+0.666	+0.124	<.001	<.001	3	6
UCEC	FGD2 →	+0.427	+0.127	.002	<.001	3	6
LSCC	WAS →	+0.680	+0.109	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046874 vs TACC1 — BRCA

Explore this scatter interactively →