Quinolinate metabolic process

Across TCGA patient cohorts, RNA activity of the Quinolinate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HAAO, C1QA, and DOCK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinolinate metabolic process activity versus HAAO in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HAAO →	+0.488	+0.154	<.001	<.001	3	7
UCEC	C1QA →	+0.592	+0.159	<.001	<.001	3	5
LSCC	DOCK2 →	+0.485	+0.095	<.001	.003	3	5
LSCC	DOCK8 →	+0.470	+0.117	<.001	<.001	3	5
LSCC	ESRP1 →	-0.545	-0.106	<.001	.001	3	5
UCEC	GPSM3 →	+0.480	+0.147	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046874 vs HAAO — BRCA

Explore this scatter interactively →