Quinolinate metabolic process

Across TCGA cell cohorts, RNA activity of the Quinolinate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf58, NAA30, and MYL6B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C17orf58 grouped by Quinolinate metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C17orf58 →	+0.725	+1.340	.007	.002	3	4
UPPER_AERODIGESTIVE_TRACT	NAA30 →	-1.182	-2.129	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYL6B →	-1.534	-1.379	<.001	.006	3	4
SOFT_TISSUE	RPL37 →	+0.863	+1.414	.002	<.001	3	3
BLOOD_Myeloma	MT-ND2 →	-1.143	-1.827	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ATP5MPL →	-1.264	-1.782	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C17orf58 by Quinolinate metabolic process activity — KIDNEY

Explore this box plot interactively →