Quinolinate metabolic process

Across TCGA cell cohorts, RNA activity of the Quinolinate metabolic process pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Vismodegib, Paclitaxel, and EPZ004777, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Vismodegib grouped by Quinolinate metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Vismodegib →	-0.597	-1.739	.048	<.001	3	1
BLOOD_Lymphoma	Paclitaxel →	-0.609	-1.855	.041	.002	3	1
BLOOD_Lymphoma	EPZ004777 →	-0.597	-1.739	.001	<.001	3	1
BLOOD_Lymphoma	ICL1100013 →	-1.168	-1.642	.019	<.001	3	1
BLOOD_Lymphoma	Entinostat →	-0.777	-1.739	.006	<.001	3	1
BLOOD_Lymphoma	AZD5991 →	-2.635	-1.868	.023	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vismodegib by Quinolinate metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →