Negative regulation of bone remodeling

Across TCGA patient cohorts, RNA activity of the Negative regulation of bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00426, ZBP1, and IKZF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of bone remodeling activity versus LINC00426 in HNSC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC00426 →	+0.709	+0.894	<.001	<.001	3	8
HNSC	ZBP1 →	+0.947	+0.634	<.001	<.001	3	7
GBM	IKZF1 →	+0.975	+0.272	<.001	<.001	3	7
GBM	GIMAP2 →	+0.796	+0.502	<.001	<.001	3	7
LSCC	CCRL2 →	+0.633	+0.848	.001	<.001	3	7
GBM	SLAMF6 →	+0.685	+0.175	<.001	.003	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046851 vs LINC00426 — HNSC

Explore this scatter interactively →