Filopodium assembly

Across TCGA cell cohorts, RNA activity of the Filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF615, CWC15, and AP4M1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF615 grouped by Filopodium assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF615 →	+0.709	+0.895	.002	.003	3	4
KIDNEY	CWC15 →	-0.514	-0.826	.006	.005	3	4
STOMACH	AP4M1 →	-1.000	-1.105	.004	.001	3	4
BLOOD_Myeloma	ID1 →	+1.782	+1.106	.005	.006	3	3
LARGE_INTESTINE	CTSH →	-1.908	-1.039	.004	.003	3	3
BREAST	MFSD6 →	+0.855	+1.056	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF615 by Filopodium assembly activity — SOFT_TISSUE

Explore this box plot interactively →