Carbohydrate phosphorylation

Across TCGA patient cohorts, RNA activity of the Carbohydrate phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBKS, SPP1_S234, and NCOR1_S1533, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate phosphorylation activity versus RBKS in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBKS →	+0.677	+0.068	<.001	.002	3	5
LSCC	SPP1_S234 →	+1.220	+0.032	<.001	.005	3	5
UCEC	NCOR1_S1533 →	-0.504	-0.075	.002	<.001	3	4
PDAC	SPP1_S263 →	+0.899	+0.033	.001	.001	3	4
LUAD	DPYD_S905 →	+0.596	+0.036	<.001	.002	3	4
PDAC	ENO1 →	+0.278	+0.034	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046835 vs RBKS — UCEC

Explore this scatter interactively →