Carbohydrate phosphorylation

Across TCGA pan-cancer cohorts, RNA activity of the Carbohydrate phosphorylation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Carbohydrate phosphorylation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and KIRP, show the opposite pattern, with higher activity associated with better survival.

MESO, BLCA, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.259	0.455	<.001	119	view →
BLCA	OS	Median	IV	0.331	0.587	<.001	70	view →
ACC	OS	Tertile	All	0.930	0.443	<.001	68	view →
CHOL	DFS	Median	II,III,IV	0.106	0.509	<.001	57	view →
LAML	DFS	Median	All	0.212	0.581	<.001	24	view →
LGG	OS	Tertile	All	0.719	0.856	<.001	23	view →
THCA	OS	Median	II,III,IV	0.547	1.000	.002	23	view →
KIRP	OS	Tertile	II,III,IV	0.955	0.494	.020	21	view →
OV	OS	Median	III,IV	0.263	0.352	.006	20	view →
SCLC	DFS	Median	II,III,IV	0.142	0.471	.004	17	view →
ESCA	OS	Quartile	II,III,IV	0.217	1.000	.004	15	view →
SKCM	OS	Quartile	All	0.455	0.272	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0046835–MESO (OS)

Open the MESO breakdown →