Carbohydrate phosphorylation

Across TCGA patient cohorts, RNA activity of the Carbohydrate phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT5, SNX18P3, and OLFM5P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate phosphorylation activity versus B4GALT5 in GBM (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	B4GALT5 →	-0.497	-0.190	<.001	<.001	3	4
GBM	SNX18P3 →	+0.812	+0.143	.005	.009	3	4
PDAC	OLFM5P →	-0.279	-0.171	.007	<.001	3	3
OV	HS2ST1 →	-0.311	-0.118	.008	.004	3	3
OV	ADRA1B →	-0.857	-0.131	.001	.005	3	3
LSCC	TIMD4 →	-0.531	-0.139	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046835 vs B4GALT5 — GBM

Explore this scatter interactively →