Carbohydrate phosphorylation

Across TCGA cell cohorts, RNA activity of the Carbohydrate phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGEF1, MAPKAPK3, and USP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAGEF1 grouped by Carbohydrate phosphorylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAGEF1 →	+0.610	+1.148	.002	<.001	3	4
SOFT_TISSUE	MAPKAPK3 →	-2.052	-1.657	.001	<.001	3	4
BONE	USP4 →	-0.670	-1.089	.002	.002	2	4
UPPER_AERODIGESTIVE_TRACT	POLR2I →	-0.568	-1.143	.005	.007	3	3
UPPER_AERODIGESTIVE_TRACT	DVL1 →	-0.657	-0.919	.006	.002	3	3
UPPER_AERODIGESTIVE_TRACT	UBE2J2 →	-0.801	-1.193	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAGEF1 by Carbohydrate phosphorylation activity — BONE

Explore this box plot interactively →