Carbohydrate phosphorylation

Across TCGA cell cohorts, RNA activity of the Carbohydrate phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK8IP1, POLD3, and ARL10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK8IP1 grouped by Carbohydrate phosphorylation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAPK8IP1 →	+0.207	+0.106	.001	<.001	3	4
LUNG_SCLC	POLD3 →	+0.499	+0.094	<.001	.002	3	4
BLOOD_Lymphoma	ARL10 →	+0.290	+0.105	.006	.009	3	4
KIDNEY	ZNF433 →	+0.208	+0.116	.002	.006	3	4
STOMACH	FSBP →	+0.381	+0.073	<.001	.001	3	4
KIDNEY	BARX2 →	+0.254	+0.129	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK8IP1 by Carbohydrate phosphorylation activity — LUNG_SCLC

Explore this box plot interactively →