Positive regulation of RNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Positive regulation of RNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53TG5, CAPN10, and ANKMY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA export from nucleus activity versus TP53TG5 in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TP53TG5 →	+0.285	+0.141	.002	.002	3	3
CCRCC	CAPN10 →	+0.264	+0.207	<.001	<.001	3	3
CCRCC	ANKMY1 →	+0.214	+0.188	.004	.001	3	3
COAD	ING5 →	+0.299	+0.168	.002	.002	3	3
CCRCC	ZNF335 →	+0.233	+0.172	.002	<.001	3	3
CCRCC	RN7SKP74 →	+0.295	+0.141	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046833 vs TP53TG5 — CCRCC

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