Regulation of RNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of RNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLC, TPM2, and PRR15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCLC grouped by Regulation of RNA export from nucleus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GCLC →	+1.412	+0.131	.002	.007	3	5
LUNG_SCLC	TPM2 →	-3.235	-0.236	.002	<.001	3	5
STOMACH	PRR15 →	+2.675	+0.154	.001	.002	3	5
STOMACH	EPHB3 →	+2.108	+0.188	<.001	<.001	3	4
LUNG_SCLC	ARMH3 →	-0.628	-0.243	.001	.001	3	4
STOMACH	IL20RA →	+2.245	+0.212	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCLC by Regulation of RNA export from nucleus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →