Positive regulation of nucleocytoplasmic transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMBOX1, RNF223, and MED15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleocytoplasmic transport activity versus HMBOX1 in SKIN (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMBOX1 →	-0.890	-0.127	<.001	.001	3	5
URINARY_TRACT	RNF223 →	+3.225	+0.165	<.001	.002	3	5
LUNG_SCLC	MED15 →	+0.517	+0.109	.003	.002	3	5
LUNG_NSCLC_LUAD	SERTAD4 →	+1.477	+0.147	<.001	<.001	3	4
SKIN	C12orf4 →	-0.627	-0.110	.001	.001	3	4
LUNG_SCLC	TP53 →	+1.381	+0.125	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046824 vs HMBOX1 — SKIN

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