Regulation of nucleocytoplasmic transport

Across TCGA patient cohorts, RNA activity of the Regulation of nucleocytoplasmic transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPFIBP1, TIMP2, and CNN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleocytoplasmic transport activity versus PPFIBP1 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPFIBP1 →	+0.291	+0.023	.003	.008	3	7
BRCA	TIMP2 →	+0.669	+0.030	<.001	<.001	3	7
BRCA	CNN3 →	+0.576	+0.024	<.001	<.001	3	7
OV	COX4I1 →	-0.369	-0.050	<.001	<.001	3	7
OV	CTHRC1 →	+0.976	+0.047	.001	.001	3	7
OV	LUM →	+0.771	+0.043	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046822 vs PPFIBP1 — LSCC

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