Microtubule polymerization

Across TCGA patient cohorts, RNA activity of the Microtubule polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PFN2, MAN2A1, and MAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization activity versus PFN2 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PFN2 →	+0.740	+0.058	<.001	.001	3	7
HNSC	MAN2A1 →	-0.329	-0.052	<.001	<.001	3	6
LSCC	MAP2 →	+0.574	+0.027	<.001	<.001	3	6
GBM	EEF2_T57 →	-0.403	-0.041	.004	.005	2	7
LUAD	MAP1B_S614 →	+1.377	+0.034	<.001	<.001	3	6
LSCC	RPL26 →	-0.521	-0.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046785 vs PFN2 — HNSC

Explore this scatter interactively →