Microtubule polymerization

Across TCGA patient cohorts, RNA activity of the Microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLP1, MVP, and IL2RA, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization activity versus PLP1 in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLP1 →	+0.773	+0.987	.002	<.001	3	2
COAD	MVP →	-0.439	-0.709	.002	.001	3	2
COAD	IL2RA →	+0.557	+0.618	.007	.007	3	2
BRCA	N4BP1 →	-0.613	-0.301	.002	.001	3	1
BRCA	VPS35L →	-0.725	-0.298	.008	.003	3	1
BRCA	ZNF200 →	-0.514	-0.277	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046785 vs PLP1 — COAD

Explore this scatter interactively →