Microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Microtubule polymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCO, ARHGAP25, and C6orf136, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARCO grouped by Microtubule polymerization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MARCO →	+0.204	+0.224	.001	.001	3	3
LUNG_SCLC	ARHGAP25 →	-0.212	-0.229	.002	.002	3	3
SKIN	C6orf136 →	-0.208	-0.199	.002	.004	3	3
BLOOD_Lymphoma	ELOVL4 →	-0.403	-0.127	.006	.005	3	3
UPPER_AERODIGESTIVE_TRACT	EBF1 →	-0.122	-0.418	<.001	.001	3	3
BLOOD_Lymphoma	RASIP1 →	+0.170	+0.127	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARCO by Microtubule polymerization activity — PANCREAS

Explore this box plot interactively →