Viral budding

Across TCGA patient cohorts, RNA activity of the Viral budding pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF13B, PRSS21, and KL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral budding activity versus KIF13B in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF13B →	+1.010	+0.146	<.001	<.001	3	4
OV	PRSS21 →	-1.270	-0.123	.006	.008	3	4
BRCA	KL →	+0.630	+0.129	<.001	<.001	3	4
BRCA	YARS1 →	-0.372	-0.080	<.001	.009	3	4
HNSC	C10orf88B →	-0.578	-0.114	.003	.008	3	3
LSCC	ZNF665 →	+0.456	+0.141	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046755 vs KIF13B — BRCA

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