Non-lytic viral release

Across TCGA patient cohorts, RNA activity of the Non-lytic viral release pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPGP12, C5, and ILDR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-lytic viral release activity versus SNRPGP12 in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPGP12 →	-0.609	-0.113	.002	.001	3	4
LUAD	C5 →	-0.724	-0.095	.003	.001	3	3
LSCC	ILDR1 →	+0.519	+0.125	.007	.008	3	3
HNSC	SLC39A6 →	+0.466	+0.125	.002	.001	3	3
COAD	DNAJB6P2 →	+0.131	+0.136	.003	.003	3	3
OV	MIR8055 →	+0.614	+0.166	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046753 vs SNRPGP12 — GBM

Explore this scatter interactively →