Acid secretion

Across TCGA patient cohorts, RNA activity of the Acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBP1, AMPH, and LILRB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acid secretion activity versus PCBP1 in LUAD (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCBP1 →	-0.209	-0.388	.008	.001	3	4
GBM	AMPH →	+0.911	+0.389	<.001	<.001	3	4
COAD	LILRB2 →	-0.578	-0.568	.002	<.001	3	4
COAD	NFAM1 →	-0.491	-0.579	.005	.005	3	4
GBM	CCT6B →	+0.264	+0.439	.001	.003	3	4
GBM	ASCL2 →	-0.424	-0.519	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046717 vs PCBP1 — LUAD

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