Acid secretion

Across TCGA cell cohorts, RNA activity of the Acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH14, GPT, and SNORC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAH14 grouped by Acid secretion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNAH14 →	+2.710	+0.969	.004	.009	3	4
KIDNEY	GPT →	-0.833	-0.985	.004	.001	3	3
KIDNEY	SNORC →	-1.385	-1.307	.001	<.001	3	3
KIDNEY	CCDC154 →	-0.740	-1.202	.001	.001	3	3
OESOPHAGUS	TIFA →	+0.778	+1.191	.008	.009	3	3
LUNG_SCLC	SLC2A4RG →	+1.419	+0.249	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAH14 by Acid secretion activity — STOMACH

Explore this box plot interactively →