Muscle cell cellular homeostasis

Across TCGA cell cohorts, RNA activity of the Muscle cell cellular homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG3, C14orf28, and PFKM, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell cellular homeostasis activity versus BAG3 in STOMACH (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BAG3 →	+1.369	+0.144	<.001	<.001	3	13
LUNG_SCLC	C14orf28 →	-0.430	-0.130	<.001	.001	3	11
URINARY_TRACT	PFKM →	+1.234	+0.163	.006	.002	3	10
OESOPHAGUS	GGPS1 →	-1.057	-0.191	.006	.001	3	9
OESOPHAGUS	ZNF75D →	-0.887	-0.162	.006	.006	2	10
URINARY_TRACT	C2orf15 →	-1.495	-0.157	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046716 vs BAG3 — STOMACH

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