GDP metabolic process

Across TCGA patient cohorts, RNA activity of the GDP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR89, LPCAT2, and RTN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP metabolic process activity versus WDR89 in COAD (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WDR89 →	-0.419	-0.065	.003	<.001	3	8
PDAC	LPCAT2 →	+0.404	+0.050	.001	<.001	3	7
BRCA	RTN1 →	+0.435	+0.034	<.001	<.001	3	7
GBM	TYROBP →	+0.527	+0.059	.001	.002	3	7
CCRCC	CARD11 →	+0.538	+0.055	<.001	<.001	3	7
LSCC	RTCB →	-0.142	-0.079	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046710 vs WDR89 — COAD

Explore this scatter interactively →