Response to cadmium ion

Across TCGA cell cohorts, RNA activity of the Response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF687, NME7, and HSF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF687 grouped by Response to cadmium ion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF687 →	+0.786	+0.193	.001	.002	3	6
URINARY_TRACT	NME7 →	+1.460	+0.454	.006	.002	3	4
BREAST	HSF4 →	+1.123	+0.218	.001	<.001	3	4
OVARY	PRPF3 →	+0.855	+0.281	.002	.002	3	4
LUNG_NSCLC_LUAD	PRKAB2 →	+0.757	+0.145	.001	.002	3	4
LIVER	LYPLAL1 →	+1.186	+0.232	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF687 by Response to cadmium ion activity — BREAST

Explore this box plot interactively →