Response to cadmium ion

Across TCGA cell cohorts, RNA activity of the Response to cadmium ion pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAP1L4, SGTA, and TUBB4B, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cadmium ion activity versus NAP1L4 in LIVER (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NAP1L4 →	+1.362	+0.355	.002	.001	3	15
STOMACH	SGTA →	+1.995	+0.385	.003	<.001	3	14
STOMACH	TUBB4B →	+1.986	+0.318	<.001	<.001	3	14
OVARY	BTF3 →	+2.180	+0.278	<.001	.001	3	14
STOMACH	UBE2L3 →	+1.969	+0.438	.001	<.001	3	14
STOMACH	PSMA3 →	+1.494	+0.445	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046686 vs NAP1L4 — LIVER

Explore this scatter interactively →