Response to arsenic-containing substance

Across TCGA patient cohorts, RNA activity of the Response to arsenic-containing substance pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN_S1349, C1S, and THBS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to arsenic-containing substance activity versus VCAN_S1349 in CCRCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCAN_S1349 →	+0.829	+0.042	.002	<.001	2	6
BRCA	C1S →	+0.454	+0.035	<.001	<.001	3	5
COAD	THBS2 →	+1.669	+0.026	<.001	<.001	3	5
CCRCC	VCAN_S2116 →	+0.861	+0.041	<.001	<.001	3	5
GBM	SULF1 →	+0.860	+0.040	<.001	<.001	3	5
CCRCC	DBN1 →	+0.264	+0.039	.005	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046685 vs VCAN_S1349 — CCRCC

Explore this scatter interactively →