Response to arsenic-containing substance

Across TCGA patient cohorts, RNA activity of the Response to arsenic-containing substance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMPD1, STMN2, and SAMD15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to arsenic-containing substance activity versus SMPD1 in BRCA (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMPD1 →	-0.604	-0.168	.002	.005	3	4
OV	STMN2 →	-0.563	-0.135	.003	.004	3	4
LUAD	SAMD15 →	-0.440	-0.124	.008	.003	3	4
LUAD	TMEM59 →	-0.428	-0.161	<.001	<.001	3	4
LUAD	DOCK2 →	+0.341	+0.117	.002	<.001	3	4
LUAD	DOK3 →	+0.577	+0.148	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046685 vs SMPD1 — BRCA

Explore this scatter interactively →