Response to arsenic-containing substance

Across TCGA cell cohorts, RNA activity of the Response to arsenic-containing substance pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC148, BEND7, and CPQ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to arsenic-containing substance activity versus CCDC148 in SOFT_TISSUE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC148 →	+0.721	+0.271	.002	<.001	3	5
SOFT_TISSUE	BEND7 →	+2.702	+0.297	.004	<.001	3	5
LUNG_NSCLC_LUSC	CPQ →	+2.214	+0.239	<.001	<.001	3	5
STOMACH	FZD4 →	+2.657	+0.338	<.001	<.001	3	5
LUNG_SCLC	CNNM3 →	+0.820	+0.240	<.001	.001	3	4
LARGE_INTESTINE	ZBTB47 →	+1.454	+0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046685 vs CCDC148 — SOFT_TISSUE

Explore this scatter interactively →