Response to organophosphorus

Across TCGA cell cohorts, RNA activity of the Response to organophosphorus pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FARSA, NAT10, and ZNF485, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to organophosphorus activity versus FARSA in BONE (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FARSA →	-1.146	-0.284	<.001	.001	3	5
PANCREAS	NAT10 →	-1.237	-0.195	<.001	<.001	3	5
LARGE_INTESTINE	ZNF485 →	-0.764	-0.231	.001	.007	3	5
SOFT_TISSUE	DZIP1L →	-1.053	-0.315	<.001	<.001	3	5
BLOOD_Lymphoma	TLN1 →	-1.014	-0.213	<.001	.009	3	4
BLOOD_Lymphoma	ZNF672 →	-0.737	-0.191	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046683 vs FARSA — BONE

Explore this scatter interactively →