Response to antibiotic

Across TCGA patient cohorts, RNA activity of the Response to antibiotic pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L3, ADH1B, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to antibiotic activity versus EPB41L3 in OV (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EPB41L3 →	+0.571	+0.036	<.001	<.001	3	8
OV	ADH1B →	+1.091	+0.036	.005	.005	2	8
LSCC	RSU1 →	+0.383	+0.056	<.001	<.001	3	6
OV	TLN1 →	+0.283	+0.042	<.001	<.001	3	6
LSCC	FRZB →	+0.608	+0.064	<.001	<.001	3	6
BRCA	HAAO →	+0.631	+0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046677 vs EPB41L3 — OV

Explore this scatter interactively →