Response to antibiotic

Across TCGA cell cohorts, RNA activity of the Response to antibiotic pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1E2, NUP153, and ITGAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKR1E2 grouped by Response to antibiotic-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AKR1E2 →	+0.194	+0.073	.005	<.001	3	4
SOFT_TISSUE	NUP153 →	+0.236	+0.100	.009	.002	3	4
SOFT_TISSUE	ITGAL →	-0.135	-0.094	.002	<.001	3	4
OESOPHAGUS	LRRCC1 →	+0.114	+0.132	.007	.001	3	4
CNS	KCNG4 →	+0.257	+0.032	<.001	.005	3	4
CNS	EFHC1 →	+0.215	+0.058	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKR1E2 by Response to antibiotic activity — OVARY

Explore this box plot interactively →